Despite being together for more than ten years, Christie and Alex had never given birth.
During this period, however, they gave their careers their whole attention, which also caused them to become increasingly aloof.
Typically, Christie and Alex would eat at a modest restaurant on special occasions like Valentine’s Day and their anniversary. But as time passed, Christie longed for more from these outings, which had turned into more of a habit than amorous encounters.
Christie had always wanted to travel the world, see various cultures firsthand, and create treasured memories. She saw this dream as a means of fortifying their relationship because they wouldn’t have any kids to bind them.
But Alex always turned down her offers to travel, claiming it would be too costly and that they should put money up for their retirement. Consequently, Christie felt her life was turning into a pattern of work and sleep, and her once-bright love started to fade.
When Alex was given a rare cancer diagnosis, tragedy struck, forcing Christie to deal with her waning feelings and the realization that his time with her was running out.
Christie once got a call from the hospital when she was traveling home from work. “Mrs. Carson, your husband is not in good condition,” the nurse said in a somber tone. It is advisable that you come over here right now.
Feeling overwhelmed by emotions, Christie hurried to the hospital, questioning why their relationship had failed. Alex was scarcely able to talk when she came, but he made an effort to express his emotions.
“Christie, even if I didn’t get the chance to show you how much I love you, please know that you are my everything. He stated to her, “I recognized at one point that this love might not be mutual between us.
The sorrow he was hiding behind his words was evident in his laborious breathing. Christie went on, “I do love you, Christie, and I didn’t expect to leave this world so early,” tears welling up in his eyes. I had a tonne of plans for us.
“These are my last hours, and there’s nothing more I’d like to spend them with,” Alex said, reaching out for her hand and taking it. I also want to take a little piece of you with me when I pass away. Therefore, if you could, please place something in my pocket at my burial so I can keep it forever.
Christie, overcome, retorted, “Alex, I swear to do that.” Be at ease regarding me. I’ll look after my needs. You may relax and keep an eye on me from up there.
They sat in soothing calm, listened to music, and relived treasured moments during their last hours together. Alex closed his eyes gently as darkness fell and never opened them again.
Christie tucked her locket—a charming memento of their love—into his coat pocket during his funeral. She discovered a message written in Alex’s handwriting inside his pocket, which said:
To Christie,
I’m happy that I choose to spend the rest of my life with you because I’ve loved you my entire life. We became distant somewhere along the line, and I apologize for forgetting to live in the present while trying to show you how much I loved you.
When we were younger, you used to tell me about your long-held ambition of opening a cafe by the seaside where you could bake your delectable cake recipes and feed patrons substantial meals. This was something I never forgot, and it gave me daily incentive to work really hard. I apologize for neglecting you during this period as it consumed all of my attention.
Christie, I came very close to witnessing you realize this dream. I have a bank passbook in my safe that is registered in your name. I have enough money saved up there for you to start your company. Documents pertaining to the acquisition of a piece of land including a tiny cottage with a view of the ocean are also contained in an envelope. This is where your cafe can be installed.
I had not intended to depart from this life so soon. Together, I wanted to start this cafe. I apologize for not being there to support you while you turn this into a reality, but know that I will always be in my thoughts and prayers.
I will always adore you with all of my heart. Alex.
Christie hoped she could go back in time because she was so moved. She talked to Alex about his unmet hopes and prayers, and over time she gained the courage to take action.
Christie realized her lifetime dream of opening “Uncle Alex’s Seaside Cafe” in honor of her late spouse. It was a monument to unwavering love and a sobering reminder that sometimes the spark of desire and love needs to be reignited by a devastating loss.
We’ve All Waited for It: Scientists Created a Drug That Can Help Regrow Lost Teeth
The tooth fairy is a welcome guest for any child who has lost a tooth. Not only will the fairy leave a small gift under the child’s pillow, but they be assured of a replacement tooth in a few months. Unfortunately, the scenario is quite different for adults grappling with a loss of teeth. Luckily, there may be some hope thanks to a new study performed by scientists at Kyoto University and the University of Fukui.
A dental breakthrough
While the typical adult mouth houses 32 teeth, approximately 1% of the population exhibits variations of them, either possessing more or fewer teeth due to congenital conditions. Researchers have delved into the genetic factors behind cases of excessive teeth, seeking valuable insights into the potential regeneration of teeth in adults. This study is the first to show that monoclonal antibodies can help regrow teeth. It suggests a new way to treat a dental problem that currently requires implants and other artificial solutions.
A bit of science
The research team disclosed that an antibody targeting a specific gene, known as uterine sensitization-associated gene-1 (USAG-1), can induce tooth development in mice affected by tooth agenesis, a congenital condition. The findings were published in the journal, Science Advances.
As per Katsu Takahashi, a senior lecturer at the Kyoto University Graduate School of Medicine and one of the principal contributors to the study, the essential molecules crucial for the development of teeth have already been pinpointed. “The morphogenesis of individual teeth depends on the interactions of several molecules including BMP, or bone morphogenetic protein, and Wnt signaling,” says Takahashi.
On April 13, 2021, the University of Kyoto posted its first pic of newly-grown teeth in mice.
BMP and Wnt are involved in more than just tooth development; they affect the growth of organs and tissues early in the body’s development. Because drugs affecting them directly might have broad side effects, scientists are cautious. To find a potentially safer method, researchers focused on the gene USAG-1, thinking that aiming at factors countering BMP and Wnt specifically in tooth development could be more precise.
“We knew that suppressing USAG-1 benefits tooth growth. What we did not know was whether it would be enough,” added Takahashi.
The first results
Scientists looked at how different monoclonal antibodies affect USAG-1. Monoclonal antibodies are often used to treat things like cancer and arthritis and for making vaccines. Tests with this antibody showed that BMP signaling is crucial for deciding the number of teeth in mice. Also, just one treatment was enough to grow a whole tooth. Further tests confirmed these positive results in ferrets too.
“Ferrets are diphyodont animals with similar dental patterns to humans. Our next plan is to test the antibodies on other animals, such as pigs and dogs,” explained Takahashi.
Fully regrown frontal teeth in ferrets
The next steps
Now, scientists are going to test the drug on healthy adults. If that goes well, the team plans to try it on kids aged 2 to 6 with a rare tooth problem called anodontia, a genetic disorder defined as the absence of all teeth. These kids will get one shot of the drug to see if it makes their teeth grow. If everything works out, the medicine might be approved by 2030.
Takahashi sees the new medicine as an additional choice for individuals who are missing some or all of their teeth.
“The idea of growing new teeth is every dentist’s dream,” Takahashi told the Japanese newspaper, The Mainichi in June this year. “I’ve been working on this since I was a graduate student. I was confident I’d be able to make it happen.”
So hopefully, by the year 2030, humans will get a chance to have their third generation of teeth grown and say goodbye to implants. Until then, make sure to keep your teeth strong and healthy — this article will help you with that.
Preview photo credit KyotoU_News / Twitter
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