The tooth fairy is a welcome guest for any child who has lost a tooth. Not only will the fairy leave a small gift under the child’s pillow, but they be assured of a replacement tooth in a few months. Unfortunately, the scenario is quite different for adults grappling with a loss of teeth. Luckily, there may be some hope thanks to a new study performed by scientists at Kyoto University and the University of Fukui.
A dental breakthrough
While the typical adult mouth houses 32 teeth, approximately 1% of the population exhibits variations of them, either possessing more or fewer teeth due to congenital conditions. Researchers have delved into the genetic factors behind cases of excessive teeth, seeking valuable insights into the potential regeneration of teeth in adults. This study is the first to show that monoclonal antibodies can help regrow teeth. It suggests a new way to treat a dental problem that currently requires implants and other artificial solutions.
A bit of science
The research team disclosed that an antibody targeting a specific gene, known as uterine sensitization-associated gene-1 (USAG-1), can induce tooth development in mice affected by tooth agenesis, a congenital condition. The findings were published in the journal, Science Advances.
As per Katsu Takahashi, a senior lecturer at the Kyoto University Graduate School of Medicine and one of the principal contributors to the study, the essential molecules crucial for the development of teeth have already been pinpointed. “The morphogenesis of individual teeth depends on the interactions of several molecules including BMP, or bone morphogenetic protein, and Wnt signaling,” says Takahashi.
On April 13, 2021, the University of Kyoto posted its first pic of newly-grown teeth in mice.
BMP and Wnt are involved in more than just tooth development; they affect the growth of organs and tissues early in the body’s development. Because drugs affecting them directly might have broad side effects, scientists are cautious. To find a potentially safer method, researchers focused on the gene USAG-1, thinking that aiming at factors countering BMP and Wnt specifically in tooth development could be more precise.
“We knew that suppressing USAG-1 benefits tooth growth. What we did not know was whether it would be enough,” added Takahashi.
The first results
Scientists looked at how different monoclonal antibodies affect USAG-1. Monoclonal antibodies are often used to treat things like cancer and arthritis and for making vaccines. Tests with this antibody showed that BMP signaling is crucial for deciding the number of teeth in mice. Also, just one treatment was enough to grow a whole tooth. Further tests confirmed these positive results in ferrets too.
“Ferrets are diphyodont animals with similar dental patterns to humans. Our next plan is to test the antibodies on other animals, such as pigs and dogs,” explained Takahashi.
Fully regrown frontal teeth in ferrets
The next steps
Now, scientists are going to test the drug on healthy adults. If that goes well, the team plans to try it on kids aged 2 to 6 with a rare tooth problem called anodontia, a genetic disorder defined as the absence of all teeth. These kids will get one shot of the drug to see if it makes their teeth grow. If everything works out, the medicine might be approved by 2030.
Takahashi sees the new medicine as an additional choice for individuals who are missing some or all of their teeth.
“The idea of growing new teeth is every dentist’s dream,” Takahashi told the Japanese newspaper, The Mainichi in June this year. “I’ve been working on this since I was a graduate student. I was confident I’d be able to make it happen.”
So hopefully, by the year 2030, humans will get a chance to have their third generation of teeth grown and say goodbye to implants. Until then, make sure to keep your teeth strong and healthy — this article will help you with that.
Preview photo credit KyotoU_News / Twitter
Christopher Reeve’s son lost both his parents by age 13
Numerous accounts exist of children who have grown up to resemble their famous parents.
A number of famous children make us gasp in disbelief when we look at them, including the twin daughters of Michael J. Fox, the teenage daughter of Julia Roberts who looks just like her, and even the grandson of Elvis Presley.
Will, the 29-year-old son of Christopher Reeve, is striving to carry on his father’s inspirational legacy in addition to being a near-perfect replica of his father.
Sadly, at the age of thirteen, Christopher Reeve’s youngest son had to cope with the loss of both of his parents.
A scene from the 1978 movie “Superman,” starring Christopher Reeve as Superman. (Photo via Getty Images))
How does a hero appear?
Growing up in the late 1970s and early 1980s, Christopher Reeve was a hero to millions of people.
When the DC comic book character Superman first appeared on television in 1978, he won a BAFTA for Most Promising Male Newcomer.
Superman II, Superman III, and Superman IV: The Quest for Peace are the three further superhero films in which the endearing and attractive actor starred.
We will always remember the well-known superhero that goes by his name.
But in addition to being an actor, Christopher Reeve (born in New York in 1952) was also a screenwriter, producer, director of films, campaigner, and horseback rider.
Accident involving Christopher Reeve
Christopher Reeve’s life would forever alter on May 27, 1995.
The well-liked actor suffered a spinal cord injury after falling off his horse Buck at an equestrian competition in Culpeper, Virginia.
The Hollywood actor became wheelchair-bound and paralyzed from the neck down, shocking millions of fans and his family.
Christopher’s mother pleaded with the medical staff to discontinue his mechanical ventilation and allow him pass away, according to the actor’s foundation.
The actor would have died instantly if he had fallen one centimeter farther to the left, according to information subsequently disclosed by the New York Times. In contrast, Christopher would have most likely only sustained a concussion if he had landed slightly to the right.
Christopher became quadriplegic while he was just 42 years old. For the remainder of his life, he needed a portable ventilator and was confined to a wheelchair.
Physicians promptly announced that there was little chance of recovery, telling Reeve in particular that it would be “impossible” for him to regain any movement.
In the early days of his hospital stay, Christopher Reeve was incoherent and highly drugged. He was going through hell. He believed his life had been ruined after learning the terrible diagnosis from the doctor.
In an attempt to spare his family from further hardship, he suggested to his wife Dana Morosini that they might as well end the relationship.
“I will support whatever you want to do because this is your life and your decision,” she said, her eyes welling with sorrow. But I want you to know that no matter what, I’ll be by your side for the entire journey. You remain who you are. I also adore you.
Reeve had the option to give up, but he chose to dedicate himself to activism and founded the Christopher Reeve Foundation with his loving wife Dana. Later on, the Christopher & Dana Reeve Foundation became its new name.
Additionally, the pair co-founded the Reeve-Irvine Research Center, which advocates for stem cell research and patients of spinal cord injuries.
To ensure his son had a happy childhood, Christopher Reeve also made the decision to do everything in his power.
In a 2016 interview with PEOPLE, Will talked candidly about his incredible upbringing, which he described as “completely typical.”
Will recalled them with affection, saying, “They were the ones who told me to go to bed, eat my broccoli, and turn off the TV.” “It was a totally normal childhood, but I understand that not every child experiences seeing their dad on the magazine at the checkout aisle when they go to the grocery store.”
Will also recalled the day his father showed him how to use a wheelchair to ride a bike. “I didn’t think it would succeed. “I’m scared, but I can hear my dad saying, ‘Steady, steady, left, right, left, right,’” he remarked. “By the third lap, I’m grinning and waving at my dad, and he’s grinning, too.” That had great meaning for him. I would race in a wheelchair later on. He would permit me to triumph.
Regretfully, just as they were reassembling everything, Will’s father passed away.
Death of Christopher Reeve
Christopher Reeve has numerous health issues even as a small child. His breathing was hampered by allergies and asthma.
He also discovered at the age of sixteen that he had alopecia areata, which was the reason of his hair loss. During his acting career, Christopher managed to manage the condition; nevertheless, upon becoming disabled, he made the decision to completely cut off all of his hair.
Christopher had multiple infections treated in the early 2000s. He was receiving treatment for an infected pressure ulcer that was resulting in sepsis in October 2004. While he was watching his son Will play hockey on October 9, Christopher had a heart attack that same evening as a result of receiving medication for his sickness.
The physicians were at a loss for what to do once he went into a coma.
At 52 years old, Christopher Reeve passed away on October 10, 2004.
Reeve’s death was attributed to a medication response, according to both Mrs. Dana and the doctors.
At Hartsdale, New York’s Ferncliff Cemetery, his corpse was cremated, and his ashes were dispersed.
Death of the wife
Despite never having smoked, Dana, Christopher’s spouse and caretaker, was also diagnosed with lung cancer only ten months after her husband’s passing. But in the early years of her career, Dana used to sing and perform in smokey pubs and hotel lobbies, claims Christopher P. Andersen.
On April 11, 1992, American singer and actress Dana wed actor Christopher Reeve in Williamstown, Massachusetts.
Dana, 44, passed away on March 6, 2006, following several months of fighting a malignant lung malignancy.
Willard Reeve
William Elliot “Will” Reeve, the son of Christopher and Dana, was born on June 7, 1992. Regretfully, Will was abandoned as an orphan when he was just 13 years old.
Nevertheless, Will has grown up to resemble his father, even though he has mostly avoided the spotlight up to this point.
After completing his schooling, Will is pursuing a successful career in the sports press profession.
Will, who is now 29 years old and has been handsomely bequeathed by his father, looks just like him more than ten years later.
However, what really stands out about this young man is that he is carrying on the excellent work that his parents began.
Despite the possibility of a downward spiral or mental instability following such a traumatic experience at such a young age, Will was able to avoid going down this path because of his strong moral principles and the support of his parents.
“A hero is an ordinary individual who finds the strength to persevere and endure in spite of overwhelming obstacles,” my father once said. I use this quote often to honor his legacy and instill his timeless spirit in a new generation,” he added in a Daily Mail article.
Will told his parents he would succeed in his career and now contributes to ESPN’s SportsCenter. He and his father both enjoy sports.
After serving as a production assistant and intern at “Good Morning America” while attending Middlebury College, he was hired.
He carries on the job his parents began, searching for novel treatments and spearheading the foundation’s fundraising efforts for additional technological advancements that will benefit individuals with spinal injuries.
In an interview with CBS News in 2018, Will discussed a letter he had written to himself following the death of his parents.
“I have both bad and good news to share. I’ll start with the negative because, no matter what, you always need to be aware of the full picture. And no, it won’t change. You’re at the lowest moment in your life, which is the bad news. You’ve just said your last goodbye to Mom and you’re in a hospital room in New York City,” he wrote. “You’re thirteen years old.” She is forty-four. carcinoma of the lung. Never indulged in smoking. Gone, like Dad, who passed away a year and a half ago, when you were at your lowest point. You’ve reached a new low, where you feel scared, perplexed, and incredibly depressed. However! The good news is that this is the bottom. You’re heading straight up, which is the only direction there is.
How motivating is Will Reeve, a young man?
Even though he lost both of his parents when he was quite young, he honors their memories every day with his accomplishments and attitude.
I’m sure his parents were quite proud of the progress this young man has made. He truly is an inspiration.
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