The tooth fairy is a welcome guest for any child who has lost a tooth. Not only will the fairy leave a small gift under the child’s pillow, but they be assured of a replacement tooth in a few months. Unfortunately, the scenario is quite different for adults grappling with a loss of teeth. Luckily, there may be some hope thanks to a new study performed by scientists at Kyoto University and the University of Fukui.
A dental breakthrough
While the typical adult mouth houses 32 teeth, approximately 1% of the population exhibits variations of them, either possessing more or fewer teeth due to congenital conditions. Researchers have delved into the genetic factors behind cases of excessive teeth, seeking valuable insights into the potential regeneration of teeth in adults. This study is the first to show that monoclonal antibodies can help regrow teeth. It suggests a new way to treat a dental problem that currently requires implants and other artificial solutions.
A bit of science
The research team disclosed that an antibody targeting a specific gene, known as uterine sensitization-associated gene-1 (USAG-1), can induce tooth development in mice affected by tooth agenesis, a congenital condition. The findings were published in the journal, Science Advances.
As per Katsu Takahashi, a senior lecturer at the Kyoto University Graduate School of Medicine and one of the principal contributors to the study, the essential molecules crucial for the development of teeth have already been pinpointed. “The morphogenesis of individual teeth depends on the interactions of several molecules including BMP, or bone morphogenetic protein, and Wnt signaling,” says Takahashi.
On April 13, 2021, the University of Kyoto posted its first pic of newly-grown teeth in mice.
BMP and Wnt are involved in more than just tooth development; they affect the growth of organs and tissues early in the body’s development. Because drugs affecting them directly might have broad side effects, scientists are cautious. To find a potentially safer method, researchers focused on the gene USAG-1, thinking that aiming at factors countering BMP and Wnt specifically in tooth development could be more precise.
“We knew that suppressing USAG-1 benefits tooth growth. What we did not know was whether it would be enough,” added Takahashi.
The first results
Scientists looked at how different monoclonal antibodies affect USAG-1. Monoclonal antibodies are often used to treat things like cancer and arthritis and for making vaccines. Tests with this antibody showed that BMP signaling is crucial for deciding the number of teeth in mice. Also, just one treatment was enough to grow a whole tooth. Further tests confirmed these positive results in ferrets too.
“Ferrets are diphyodont animals with similar dental patterns to humans. Our next plan is to test the antibodies on other animals, such as pigs and dogs,” explained Takahashi.
Fully regrown frontal teeth in ferrets
The next steps
Now, scientists are going to test the drug on healthy adults. If that goes well, the team plans to try it on kids aged 2 to 6 with a rare tooth problem called anodontia, a genetic disorder defined as the absence of all teeth. These kids will get one shot of the drug to see if it makes their teeth grow. If everything works out, the medicine might be approved by 2030.
Takahashi sees the new medicine as an additional choice for individuals who are missing some or all of their teeth.
“The idea of growing new teeth is every dentist’s dream,” Takahashi told the Japanese newspaper, The Mainichi in June this year. “I’ve been working on this since I was a graduate student. I was confident I’d be able to make it happen.”
So hopefully, by the year 2030, humans will get a chance to have their third generation of teeth grown and say goodbye to implants. Until then, make sure to keep your teeth strong and healthy — this article will help you with that.
Preview photo credit KyotoU_News / Twitter
Gordon Ramsay, 57, and His Wife Tana, 49, Proudly Introduced Their 6th Baby to the World
Gordon and Tana Ramsay are parents to a large brood, but they decided not to stop there and recently became parents for the 6th time. They welcomed their son, Jesse James, and shared heartwarming photos of the little one, who has already celebrated his first month.
After Gordon and Tana got married, they faced difficulties conceiving a child. Initially, Tanya was diagnosed with polycystic ovary syndrome, and later, Gordon encountered fertility issues. However, they didn’t give up and decided to try IVF. Fortunately, it worked, and in 1998, their first daughter Megan was born. But they didn’t stop there, and about a year later, the family welcomed two adorable twins, Jack and Holly.
In 2001, another addition to the family arrived. Little Matilda was born, and from the age of 9, she participated in her father’s culinary shows.
After the birth of their four children, Gordon and Tana had to endure a loss. In May 2016, they announced that they were expecting another child. However, a month later, Gordon revealed that the baby would not be born. At that time, his support was crucial for Tana. She shared that Gordon couldn’t be there when their four children were born, but he was with her at the most critical moment.
The loss only strengthened the family, and the couple became even more attentive to each other. Gordon never left Tana’s side, and in April 2019, he was there when their fifth child, Oscar, was born.
The birth of their sixth child was a miracle for the family. Gordon is 57 years old, and Tana is 49. The arrival of the new addition to the family brought out the tender side in both parents. Tana admitted that Gordon is, in fact, a very gentle and vulnerable person.
Despite Gordon’s well-known bold on-camera persona, he disclosed that his wife, Tana, is the stronger of the two. “Tana’s super fierce, an ex-Montessori school teacher. So, I’m the softie,” he said. His wife also confirmed this, “He is, believe it or not, incredibly sensitive.”
Following the baby’s birth, Gordon, 57, was the first to announce the news, sharing snapshots of their newest addition to the Ramsay family. On his Instagram gallery, the Kitchen Nightmares host captioned, “What an amazing birthday present please welcome Jesse James Ramsay, 7lbs 10oz whopper,” he captioned the post.
The heartwarming photo captured the baby boy in a snug white onesie decorated with tiny red, blue, and gray stars. Wrapped in a blanket, the little one looked more than cozy. Tana, 49, expressed her feelings in the caption, “One month of this little one already, loving every minute.”
Motherhood after 40 is becoming more and more common. Take a look at other stars who have given birth after the age of 40, and some even after 50.
Preview photo credit tanaramsay / Instagram, gordongram / Instagram
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